Technical equipment

High Pressure Reactors

High pressure reactors offer the possibility to perform chemical syntheses with participation of the gas phase elevated pressures..

Technical data
Small autoclave Volume: 50 ml, pressure: up to 150 bar,
temperature: up to 250 °C,
material: stainless steel, different sealing techniques for work with CO2 amongst others
Station of autoclaves
Four parallel reactors at laboratory scale,
pressure: up to 300 bar,
temperature: up to 400 °C,
material: Hastelloy C22

For the station software is available, which allows a detailed documentation of the reaction parameters and a thorough set of the process.

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Fermenters up to 40 liters are available for biotechnological work.

Fermentation unit Description

8-fold parallel fermenter (0.2–0.8 l working volume)

3 x 3 l Fermenter (0.5–2 l working volume)

10 l Fermenter (4–8 l working volume)

40 l Fermenter (15–30 l working volume)

Monitoring and control Temperature, mixing, pH, pO2
Exhaust gas analysis CO2, O2

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Automatic High Throughput Screening

For high throughput screenings of biocatalysts both a "Liquid Handling Station" and a "Picking Station" are available.

Automated components Description
Pipetting robot

8-channel liquid handling with level detection

96-channel liquid handling

Handling of up to 44 microtitre plates

Incubation chamber

Temperature control (20–65 °C)

Humidity control

Centrifuge 3500 g, temperature control (4–30°C)
Photometer UV-Vis, fluorescence
Picking Station

4000 colonies per hour

8-channel dispenser (5 µl, error < 3 %)

With this system it is possible to screen up to 10,000 variants per day, depending on the assay.

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Gas Chromatography (GC)

Gas Chromatography is a physical-chemical separating process both for qualitative and for quantitative analytics of of organic substances. The basic condition for that is an evaporation of the single substances without their destruction. 

GC-equipment Description
MS-detector (mass spektrometry) Identification and assigment of mixtures of unknown substances in e.g. varnishes, samples of natural substances, fragrances and odorous substances
FID (flame ionisation detector) Robust detector for organic substances with high sensitivity (detection limit 1 ng)
Headspace Method for analytics of highly volatile substances
SPME (solid phase micro extraction) Method for analytics of samples with low concentrations

For sample injection, the following systems are present: on-column, SSL (split/splitless), PTV (programmed temperature vaporizer)

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High Pressure Liquid Chromatogrphy (HPLC)

The high pressure liquid chromatography is a physical-chemical separating method for qualitative as well as quantitaive analytics of mixtures of substances. In contrast to GC, the substances for analytics (organic substances) have to be soluble in a solvent.

HPLC-equipment Description
UV/VIS Specific detection of substances with known UV/VIS absorption bands
DAD (diode-array-detector) Unspecific detection of the complete UV/VIS spectral width at each time of the chromatogram
ELSD (Evaporative light scattering detector) Detection of substances based on light scattering at particles


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400 MHz-Nuclear Magnetic Resonance Spectroscopy (NMR)

High resolution NMR spectroscopy in solution serves for structure elucidation of organic molecules in solution. Furthermore, it is possible to observe and map chemical reactions.

9,4 Tesla magnet
1H frequency 400MHz
5 mm probe
Automatic tune between 1H and 19F and between 31P and 109Ag, field gradient up to 140 G/cm
2-channel spectrometer
Measurement of 1D as well as 2D COSY-, HMQC-, HMBC-, NOESY-, ROESY-, TOCSY- and DOSY-spectra
variable temperature unit
Temperature control between -100 °C and +150 °C possible

With the support of up-to-date software, measurement parameters are individually adjustable and data analysis can be performed by routine protovols.

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