High pressure reactors offer the possibility to perform chemical syntheses with participation of the gas phase elevated pressures..
|Small autoclave||Volume: 50 ml, pressure: up to 150 bar,
temperature: up to 250 °C,
material: stainless steel, different sealing techniques for work with CO2 amongst others
|Station of autoclaves
||Four parallel reactors at laboratory scale,
pressure: up to 300 bar,
temperature: up to 400 °C,
material: Hastelloy C22
For the station software is available, which allows a detailed documentation of the reaction parameters and a thorough set of the process.
Fermenters up to 40 liters are available for biotechnological work.
8-fold parallel fermenter (0.2–0.8 l working volume)
3 x 3 l Fermenter (0.5–2 l working volume)
10 l Fermenter (4–8 l working volume)
40 l Fermenter (15–30 l working volume)
|Monitoring and control||Temperature, mixing, pH, pO2|
|Exhaust gas analysis||CO2, O2|
For high throughput screenings of biocatalysts both a "Liquid Handling Station" and a "Picking Station" are available.
8-channel liquid handling with level detection
96-channel liquid handling
Handling of up to 44 microtitre plates
Temperature control (20–65 °C)
|Centrifuge||3500 g, temperature control (4–30°C)|
4000 colonies per hour
8-channel dispenser (5 µl, error < 3 %)
With this system it is possible to screen up to 10,000 variants per day, depending on the assay.
Gas Chromatography is a physical-chemical separating process both for qualitative and for quantitative analytics of of organic substances. The basic condition for that is an evaporation of the single substances without their destruction.
|MS-detector (mass spektrometry)||Identification and assigment of mixtures of unknown substances in e.g. varnishes, samples of natural substances, fragrances and odorous substances|
|FID (flame ionisation detector)||Robust detector for organic substances with high sensitivity (detection limit 1 ng)|
|Headspace||Method for analytics of highly volatile substances|
|SPME (solid phase micro extraction)||Method for analytics of samples with low concentrations
For sample injection, the following systems are present: on-column, SSL (split/splitless), PTV (programmed temperature vaporizer)
The high pressure liquid chromatography is a physical-chemical separating method for qualitative as well as quantitaive analytics of mixtures of substances. In contrast to GC, the substances for analytics (organic substances) have to be soluble in a solvent.
|UV/VIS||Specific detection of substances with known UV/VIS absorption bands|
|DAD (diode-array-detector)||Unspecific detection of the complete UV/VIS spectral width at each time of the chromatogram
|ELSD (Evaporative light scattering detector)||Detection of substances based on light scattering at particles
High resolution NMR spectroscopy in solution serves for structure elucidation of organic molecules in solution. Furthermore, it is possible to observe and map chemical reactions.
|9,4 Tesla magnet
||1H frequency 400MHz
|5 mm probe
||Automatic tune between 1H and 19F and between 31P and 109Ag, field gradient up to 140 G/cm
||Measurement of 1D as well as 2D COSY-, HMQC-, HMBC-, NOESY-, ROESY-, TOCSY- and DOSY-spectra
|variable temperature unit
||Temperature control between -100 °C and +150 °C possible
With the support of up-to-date software, measurement parameters are individually adjustable and data analysis can be performed by routine protovols.