Array Technologies

The basic principle of a microarray or biochip is that DNA or protein molecules are fixed in an ordered fashion i.e. a defined sequence onto a solid support. For analyzing genes or genomes for example, complex samples are isolated from cells or tissues of interest, labeled and investigated using such a biochip.

Biochips enable the researcher to look at thousands of genes or proteins in parallel in a single experiment. The individual DNA or protein probes act as sensors to gain information about transcription, expression or mutations of the respective gene.

Indications

  • Sepsis
  • Respiratory diseases
  • Skin infections
  • Resistence detection

Customer-specific DNA microarrays

Automatisierte Herstellung von Microarrays mit einem Spotter

Automatisierte Herstellung von Microarrays mit einem Spotter.

The Fraunhofer IGB develops tailor-made microarrays for corporate customers, hospitals and research institutions to address a wide variety of applications.

The existing infrastructure makes it possible to develop customized microarrays from the probe design through to their immobilization by contact printing methods.

Reference projects

STD-Array – Identification of pathogens of sexually transmitted diseases with highly parallel diagnostics using DNA microarray

 

On behalf of Immundiagnostik AG Bensheim, Fraunhofer IGB is developing multiplex PCRs as a basis for DNA-based microarrays for highly parallel diagnostics of sexually transmitted infectious diseases. Automated processing of samples should enable simplified and cost-effective diagnostics in a point-of-care test.

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FYI-Chip

Detection of human fungal pathogens using a lab-on-a-chip device

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Chip for diagnosing sepsis

DNA chips for the classification of mammary carcinoma, for example, enable personalized and efficient therapy and prognosis. In addition, using molecular-genetic methods, we are developing improved diagnostic arrays for non-Hodgkin lymphoma.

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Genomic Approaches to Unravel the Molecular Mechanisms of Pathogenicity in the Human Fungal Pathogen Candida glabrata – FunPath

EUropean RESistance FUNgal – EURESFUN

Project duration: December 2005 – November 2008

The project aims to the elucidation of resistance mechanisms in human fungal pathogens resulting in a DNA array for detection of resistances.

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