The targets identified through our genome and proteome analyses are used to develop high throughput assays for the screening of compound libraries. Currently we screen combinatorial chemical libraries using assays that simultaneously measure both antifungal activity as well as the toxicity of the substances in relation to human cells.
In addition to drug screening assays, we have developed cell-based assays to detect pyrogens (e.g. remainders of bacteria) which cause febrile reactions up to septic shock in humans. These assays are ideally suited to test medical devices or pharmaceutical formulations for the absence of pyrogens and complement or replace previous pyrogen tests.