Molecular Biotechnology

Range of services

  • Screening of targets and drugs for anti-infectives (infection models, cell-based screening assays)
  • Proteome analyses (2D- / LC proteomics)
  • High-throughput sequencing of genomes and transcriptomes
  • Next-generation diagnostics of blood samples (circulating nucleic acids in plasma or serum, CNAPS)
  • Development of DNA microarrays: probe design, manufacturing of arrays, sample preparation procedures
  • Cell-based assays: antiviral assays (GLP), TLR / PRR-based assays/pyrogen detection (GLP), mutagenicity, toxicity
  • Development of production cell lines and processes for recombinant production of proteins (biosimilars, protein purification and characterization)
  • Cell-free protein synthesis, synthetic biology with nonnatural amino acids
  • Development of new high-throughput enzyme assays and screening processes
  • Strain and parameter screening in multi-fermenter systems
  • Development of integrated fermentation processes for industrial biotechnology, including the processing of both raw materials and products
  • Chemical-physical and biochemical analysis

Infrastructure and technical equipment

  • Molecular-biological laboratories conforming to safety levels L2, S1 and S2 of the German GenTSV (genetic engineering safety regulations)
  • Microarray facility, universal microarray platform
  • Quantitative real time PCR (qRT-PCR LightCycler 480)
  • High-throughput DNA parallel sequencing facility for nucleic acid analysis (Illumina HiSeq2000, Roche Junior)
  • Proteomics facility using high-resolution MS technologies (2D gel electrophoresis, nano-LC-MALDI-TOF/TOF, HPLCESI-MS/MS)
  • Fermentation plant for suspension and adherent cell cultures up to 10 liters of non-GLP
  • Plants for protein purification
  • Multi-fermentation plants for bioprocess development, and fermenters (up to 40 liters), S2/L2
  • Cell disruption equipment (ball mills, high-pressure autoclave, etc.)
  • GC-MS/MS, LC-MS/MS, IC, ICP-AES, and ICP-MS, accredited by the Deutsche Akkreditierungsstelle GmbH