Active agent formulation

A major challenge in the treatment of diseases is the selective transport of active agents to the damaged tissue or organ. Cell membranes are the most important barriers for a targeted drug delivery. Another problem is the degradation or derivatization of free agents in the body which often reduces the specific effect of the drug at the target site. Also, active agents are distributed incorrectly or are changed in the body, which may lead to unwanted side effects. An already-tested way to circumvent these disadvantages is the manufacturing of particulate active ingredient formulations, where the active agent is bound into a polymeric shell or matrix.

Fields of research

  • Formulation of loaded and biodegradable polymer particles
  • Customized polymers
  • Controlled release
  • Surface modification for efficient drug targeting

Reference projects

N2B-patch –

Development of an intranasal form of therapy for the treatment of multiple sclerosis

 

In the EU-funded research project “N2B-patch”, an international consortium is developing an intranasal application platform for biopharmaceutics against diseases of the central nervous system (CNS). Using the treatment of multiple sclerosis as an example, the "Nose2Brain“ approach intends to transport active substances formulated in biomaterials directly through the nose to the brain.

 

Duration: January 2017 – December 2020

iP-OSTEO –

Induced pluripotent stem cell seeded active osteochondral nanofibrous scaffolds

 

The iP‑OSTEO project focuses on development of novel cell‑based scaffolds for bone and cartilage repair and will deliver an effective treatment method for patients with poor regenerative capacity. The involved institutions will also help in better integration of academic and industrial stakeholders across Europe as they strengthen the partnerships and promote knowledge transfer across national borders and across different sectors.

 

Duration: February 2019 – January 2023