In-vitro diagnostics

The development and application of innovative methods concerning next-generation sequencing, as well as synthetic biology, are the main focus of the Functional Genomics research group headed by Dr. Kai Sohn. These methods provide the basis for the identification of biomarkers for personalized diagnostics of various clinical indications and the molecular analysis of infection processes, but also for the characterization of microorganisms in industrial biotechnology. Furthermore, methods for the qualitative and quantitative characterization of complex microbial metagenomes and metatranscriptomes are developed and applied to diagnostics and environmental biotechnology.

To this end, a complete workflow was established in our group to provide an 'all-in-one' solution from sample preparation to bioinformatics. Our automated sample preparation, next generation sequencing and high performance computing workflows are available for cooperation and joint research projects, as well as research projects of industrial clients.

Fields of activity and technologies

  • NGS-based diagnostics
  • Precision diagnostics and biomarkers
  • Microbiomics
  • Environmental genomics
  • Bioinformatics
 

Functional genomics via next-generation sequencing

Next-generation sequencing allows for the simultaneous sequencing of several hundred billions of nucleic acid fragments. We utilize this technology for de-novo sequencing of bacterial and fungal genomes, for transcriptional profile analyses, the identification of relevant genes and screening for diagnostic biomarkers.
 

Next-generation diagnostics

Despite good medical standards, there are still inadequate diagnostic procedures for many diseases to this day. We use next-generation sequencing technology to identify new biomarkers for improved diagnosis of, for example, prostate cancer, COPD or infectious diseases.

 

Genomics for white and environmental biotechnology

We also use NGS genome analyses to characterize microorganisms for industrial biotechnology. In addition, we develop methods for the qualitative and quantitative detection of complex microbial metagenomes and transcriptomes for environmental biotechnology.