Bioprocess scale-up

We have a broad bioprocess engineering know-how for process intensification and scale-up, whereby the processes developed on a laboratory scale are evaluated in advance with regard to their transferability to the industrial relevant scale and optimized iteratively during transfer and scale-up. These include the adaptation of process control strategies (batch, fed-batch, continuous) and integrated product purification to reduce process steps or the reuse of biocatalysts (e.g. by immobilization on carrier materials). In addition to the scale-up of processes to demonstration scale, we also provide sample quantities for application tests.

Fields of activity and technologies

Enzyme production and biocatalysis

Together with our customers, we develop, optimize and/or scale up the production of enzymes up to pilot scale. The enzyme can be purified for biocatalysis or whole-cell catalysis can be carried out.

 

Fermentative production of carboxylic acids

We are developing new economical processes for the sustainable production of malic, xylon and itaconic acid from lignocellulosic sugars. We have successfully demonstrated the production of malic acid from xylose on a 1 m³ scale.

 

Reference: Process demonstration isobutene

A novel process for the production of isobutene developed by the company Global Bioenergies is based on the fermentative production of gaseous isobutene from sugars using genetically modified microorganisms. To scale up this process, we have built up and operated a demonstration plant with a nominal capacity of 100 tonnes per year and a fermentation volume of 5000 liters.

Range of services

The team possesses broad bioprocess engineering expertise in the field of scale-up and process intensification. The processes developed on the laboratory scale are evaluated in the preliminary stages in terms of their transferability to industrially relevant equipment at scale and are optimized repetitively during transfer and scale-up. This includes, for example, the adjustment of process control strategies (batch, fed-batch, continuous) and integrated product purification to reduce the number of process steps or the reutilization of the deployed resources, e.g. by immobilization of biocatalysts on carrier materials.

The equipment in the area of biotechnological processes comprises two modularly constructed pilot plant halls of biological safety level 1, whereby one of the halls can be operated under ATEX conditions.

Equipment

The facilities include a central microbiological laboratory, two module-based technical centers of the Biosafety Level 1, one of which can be operated under ATEX conditions.

 

Cultivation

  • Fermentation of various microorganisms: reactor cascade with total volumes of 10, 100, 300, 1000 and 10,000 liters, equipped with four storage tanks each (acid, base, antifoaming agent, nutrition solution) as well as comprehensive automation, measurement and control technology (rotation speed, temperature, head space pressure, pH value, dissolved oxygen, respiration, methanol concentration)
  • UHT plant for the continuous sterilization of fermentation media
  • ATEX fermenter (total volume: 500 L) for conversion or production of highly flammable chemicals
  • Continuous process control in fermentations by cell retention (sterilizable crossflow filtration plant with automatic feed level control)
  • Online measurement of alcohol concentration in the reactor and of CO2/O2 in the fermentation exhaust gas


Enzymatic conversions 

  • Reactors for enzyme-catalyzed reactions (500 (mobile), 1300, 2000, 5000 and 10,000 liters, stirred, temperature-controlled)
  • Enzymatic hydrolysis / modification of fibers (tank with special stirrer configuration for high viscosities)


Product purifcation and finishing 

  • Harvest of the fermentation suspension as well as temporary storage of product solutions using stirred and temperature-controlled tanks (500 (mobile) / 2,000 / 5,000 and 10,000 L)
  • Biomass separation (disk separators 0.5 – 2 m3/h, 0.5 – 1 m3/h, vacuum drum cell flter 0.5 m2 and fiter press 1.6 m2)
  • Cell disruption (homogenizer 0.4 m3/h, 1,000 bar, optional with subsequent flow cooling)
  • Membrane filtration (MF/UF) for desalination and product concentration processes; feeding up to 500 kg/h; flexible use of spiral wound modules (material, cut-off)
  • Fine purification using liquid chromatography (35-liter column volume, flow rate up to 180 L/h) 
  • Crystallizers (180 L, 800 L) with downstream vacuum fiter dryer (0.5 m2) in ATEX version 
  • Spray (5 kg/h) and freeze drying (0.8 m2) for finishing the products


Analytical equipment

  • Laboratories for microbiological tests
  • Qualitative and quantitative methods to determine the optical density and cell dry mass, the concentration of sugars, alcohols and organic acids, protein analysis
  • Various assays for measuring enzyme activity
  • Online measurement of the alcohol concentration in the reactor and CO2 / O2 in the fermentation exhaust gas

Infomaterialien

 

Broschüre »Industrielle Biotechnologie - Die Natur als chemische Fabrik«

Wissenschaftliche Publikationen

Jahr
Year
Titel/Autor:in
Title/Author
Publikationstyp
Publication Type
2023 Fermentation and recovery of cellobiose lipids using foam fractionation
Oraby, Amira; Hug, Daniel; Weickardt, Isabell; Maerz, Lea; Nebel, Sabrina; Kurmann, Jasper; Rupp, Steffen; Tovar, Günter E.M.; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2023 Preliminary investigation on the effect of insect-based chitosan on preservation of coated fresh cherry tomatoes
Tafi, Elena; Triunfo, Micaela; Guarnieri, Anna; Ianniciello, Dolores; Salvia, Rosanna; Scieuzo, Carmen; Ranieri, Annamaria; Castagna, Antonella; Lepuri, Samuel; Hahn, Thomas; Zibek, Susanne; Bonis, Angela de; Falabella, Patrizia
Zeitschriftenaufsatz
Journal Article
2023 Usage of chitosan from Hermetia illucens as a preservative for fresh Prunus species fruits: a preliminary analysis
Triunfo, Micaela; Tafi, Elena; Guarnieri, Anna; Ianniciello, Dolores; Scieuzo, Carmen; Salvia, Rosanna; Hahn, Thomas; Zibek, Susanne; Falabella, Patrizia
Zeitschriftenaufsatz
Journal Article
2022 Techno-Economic Analysis as a Driver for Optimisation of Cellobiose Lipid Fermentation and Purification
Oraby, Amira; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2022 Optimization and Kinetic Modeling of a Fed-Batch Fermentation for Mannosylerythritol Lipids (MEL) Production with Moesziomyces aphidis
Beck, Alexander; Vogt, Franziska; Hägele, Lorena; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2022 Environmental Impacts of Biosurfactants from a Life Cycle Perspective
Briem, Ann-Kathrin; Bippus, Lars; Oraby, Amira; Noll, Philipp; Zibek, Susanne; Albrecht, Stefan
Aufsatz in Buch
Book Article
2022 Characterization of chitin and chitosan derived from Hermetia illucens, a further step in a circular economy process
Triunfo, M.; Tafi, E.; Guarnieri, A.; Salvia, R.; Scieuzo, C.; Hahn, Thomas; Zibek, Susanne; Gagliardini, A.; Panariello, L.; Coltelli, M.B.; Bonis , A. De; Falabella, P.
Zeitschriftenaufsatz
Journal Article
2022 Antimicrobial properties of chitosan from different developmental stages of the bioconverter insect Hermetia illucens
Guarnieri, A.; Triunfo, M.; Scieuzo, C.; Ianniciello, D.; Tafi, E.; Hahn, Thomas; Zibek, Susanne; Salvia, R.; Bonis, A. De; Falabella, P.
Zeitschriftenaufsatz
Journal Article
2022 Foam fractionation methods in aerobic fermentation processes
Oraby, Amira; Weickardt, Isabell; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2022 Overview on Glycosylated Lipids Produced by Bacteria and Fungi: Rhamno-, Sophoro-, Mannosylerythritol and Cellobiose Lipids
Zibek, Susanne; Soberón-Chávez, Gloria
Aufsatz in Buch
Book Article
2022 Purification of Chitin from Pupal Exuviae of the Black Soldier Fly
Hahn, T.; Tafi, E.; Seggern, N. von; Falabella, P.; Salvia, R.; Thomä, J.; Febel, E.; Fijalkowska, M.; Schmitt, E.; Stegbauer, L.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2021 Platform and fine chemicals from woody biomass: Demonstration and assessment of a novel biorefinery
Nitzsche, R.; Gröngröft, A.; Köchermann, J.; Meisel, K.; Etzold, H.; Verges, Marlen; Bachmann, J.; Leschinsky, Moritz; Saake, B.; Torkler, Sandra; Rößiger, B.; Patzsch, Katja; Pufky-Heinrich, D.; Unkelbach, Gerd
Zeitschriftenaufsatz
Journal Article
2021 Novel mannosylerythritol lipid biosurfactant structures from castor oil revealed by advanced structure analysis
Beck, A.; Haitz, Fabian; Thier, I.; Siems, K.; Jakupovic, S.; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2021 Genomic and Proteomic Study of Andreprevotia ripae Isolated from an Anthill Reveals an Extensive Repertoire of Chitinolytic Enzymes
Lorentzen, S.B.; Arntzen, M.; Hahn, T.; Tuveng, T.R.; Sorlie, M.; Zibek, S.; Vaaje-Kolstad, G.; Eijsink, V.G.H.
Zeitschriftenaufsatz
Journal Article
2021 Insect Chitin-Based Nanomaterials for Innovative Cosmetics and Cosmeceuticals
Triunfo, M.; Tafi, E.; Guarnieri, A.; Scieuzo, C.; Hahn, T.; Zibek, S.; Salvia, R.; Falabella, P.
Review
2020 Chitosan application in textile processing and fabric coating
Hahn, Thomas; Bossog, Leonie; Hager, Tom; Wunderlich, Werner; Breier, Rudi; Stegmaier, TThomas; Zibek, Susanne
Aufsatz in Buch
Book Article
2020 Draft Genome Sequence of Andreprevotia sp. Strain IGB-42, a Chitinolytic Bacterium Isolated from a Soil Sample of an Anthill in Stuttgart, Germany
Vainshtein, Y.; Werner, Nicole; Kirstahler, Philipp; Glanz, K.; Grumaz, Christian; Hahn, T.; Zibek, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2020 Mannosylerythritollipide - mikrobielle Biotenside aus dem Bioreaktor
Beck, A.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Antibacterial properties of glycosylated surfaces: Variation of the glucosidal moiety and fatty acid conformation of grafted microbial glycolipids
Valotteau, C.; Roelants, S.L.K.V.; Dasaiyan, P.; Zibek, S.; Günther, Michael; Soetaert, W.; Everaert, B.; Pradier, C.-M.; Babonneau, F.; Baccile, N.; Humblot, V.
Zeitschriftenaufsatz
Journal Article
2020 Determining different impact factors on the xylonic acid production using Gluconobacter oxydans DSM 2343
Hahn, T.; Torkler, S.; Bolt, R. van der; Gammel, N.; Hesse, M.; Möller, A.; Preylowski, B.; Hubracht, V.; Patzsch, K.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Factors Affecting the Synthesis of Cellobiose Lipids by Sporisorium scitamineum
Oraby, Amira; Werner, Nicole; Sungur, Z.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Growth Behavior of Selected Ustilaginaceae Fungi Used for Mannosylerythritol Lipid (MEL) Biosurfactant Production - Evaluation of a Defined Culture Medium
Beck, A.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Current state of chitin purification and chitosan production from insects
Hahn, T.; Tafi, E.; Paul, A.; Salvia, R.; Falabella, P.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Comparison of Different Lactobacilli Regarding Substrate Utilization and their Tolerance Towards Lignocellulose Degradation Products
Gubelt, A.; Blaschke, Lisa; Hahn, Thomas; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2020 A systematic analysis of economic evaluation studies of second-generation biorefineries providing chemicals by applying biotechnological processes
Jorissen, T.; Oraby, Amira; Recke, G.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Chitosan production with larval exoskeletons derived from the insect protein production
Hahn, T.; Roth, A.; Ji, R.; Schmitt, E.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2019 Biotechnological and biochemical utilization of lignin
Rais, Dominik; Zibek, Susanne
Aufsatz in Buch
Book Article
2019 Influence of microorganism and plant oils on the structure of mannosylerythritol lipid (MEL) biosurfactants revealed by a novel thin layer chromatography mass spectrometry method
Beck, Alexander; Haitz, Fabian; Grunwald, Saskia; Preuss, Laura; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2019 Selection and optimization of a suitable pretreatment method for miscanthus and poplar raw material
Seibert-Ludwig, Daniel; Hahn, Thomas; Hirth, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2019 Stirrer speed adaption is beneficial for liquefaction of cellulose
Hahn, Thomas; Nothacker, Matthias; Kövilein, Aline; Beck, Alexander; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2019 Integrated lignocellulosic value chains in a growing bioeconomy: Status quo and perspectives
Dahmen, Nicolaus; Lewandowski, Iris; Zibek, Susanne; Weidtmann, Annette
Zeitschriftenaufsatz
Journal Article
2019 Mannosylerythritol Lipids: Biosynthesis, Genetics, and Production Strategies
Beck, Alexander; Werner, Nicole; Zibek, Susanne
Aufsatz in Buch
Book Article
2018 Chemo-Enzymatic Epoxidation of Lallemantia IbericaSeed Oil
Haitz, Fabian; Radloff, S.; Rupp, S.; Fröhling, M.; Hirth, Thomas; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2018 New methods for high‐accuracy insect chitin measurement
Hahn, T.; Roth, A.; Febel, E.; Fijalkowska, M.; Schmitt, E.; Arsiwalla, T.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2018 Entwicklung von Verfahren zur enzymatischen Epoxidierung von Pflanzenölen und Fettsäurederivaten
Haitz, F.
Dissertation
Doctoral Thesis
2018 Unkraut kann auch anders. Handschuhe aus Russischem Löwenzahn
Hahn, Thomas; Abele, A.; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2018 Sewage Polluted Water Treatment via Chitosan. A Review
Hahn, Thomas; Zibek, Susanne
Aufsatz in Buch
Book Article
2017 Mannosylerythritol- und Cellobioselipide
Hahn, T.; Haitz, Fabian; Schäper, N.; Carrillo Riveros, P.; Günther, Michael; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2017 Biotechnological production of bio-based long-chain dicarboxylic acids with oleogenious yeasts
Werner, Nicole; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Development of a simplified purification method for a novel formaldehyde dismutase variant from Pseudomonas putida J3
Blaschke, Lisa; Werkmeister, Christina; Wagner, Wenke; Wild, Marion; Gihring, Adrian; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Neue Biokatalysatoren zur Herstellung langkettiger Dicarbonsäuren
Werner, Nicole; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Biotechnological Routes Towards Bio-based Surfactants
Schörken, U.; Barbe, S.; Hahn, T.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2017 Fungal Glycolipids as Biosurfactants
Günther, Michael; Zibek, S.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2017 Draft genome sequence of Pseudonocardia autotrophica strain DSM 43083, an efficient producer of peroxidases for lignin modification
Grumaz, Christian; Rais, Dominik; Kirstahler, Philipp; Vainshtein, Yevhen; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2017 Verfahren zur Herstellung von Epoxiden mit Hilfe von Enzymen mit Perhydrolaseaktivität
Zibek, Susanne
Patent
2017 Candida guilliermondii as a potential biocatalyst for the production of long-chain a,o-dicarboxylic acids
Werner, Nicole; Dreyer, Miriam; Wagner, Wenke; Papon, Nicolas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Beechwood carbohydrates for enzymatic synthesis of sustainable glycolipids
Siebenhaller, S.; Hajek, T.; Muhle-Goll, C.; Himmelsbach, M.; Luy, B.; Kirschhöfer, F.; Brenner-Weiß, G.; Hahn, T.; Zibek, S.; Syldatk, C.
Zeitschriftenaufsatz
Journal Article
2017 Sustainable carbon sources for microbial organic acid production with filamentous fungi
Dörsam, S.; Fesseler, J.; Gorte, O.; Hahn, T.; Zibek, S.; Syldatk, C.; Ochsenreither, K.
Zeitschriftenaufsatz
Journal Article
2016 Fermentative production and characterization of several tailor-made mannosylerythritol lipids
Zibek, Susanne; Günther, Michael; Carillo-Riveros, Paula; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2016 Chitin-converting enzymes
Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S.
Aufsatz in Buch
Book Article
2016 Enzymatische Synthese von Biotensiden aus der Cellulosefraktion des Organosolvprozesses
Siebenhaller, Sascha; Hajek, T.; Zibek, Susanne; Syldatk, Christoph
Zeitschriftenaufsatz
Journal Article
2016 Optimization and scale-up of inulin extraction from Taraxacum koksaghyz
Hahn, Thomas; Harms, Karsten; Wach, Wolfgang; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2016 Scale-up of the chemo-enzymatic epoxidation
Haitz, Fabian; Rupp , Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2016 Seasonal pattern of biomass and rubber and inulin of wild Russian dandelion (Taraxacum koksaghyz L. Rodin) under experimental field conditions
Kreuzberger, Marie; Hahn, Thomas; Zibek, Susanne; Schiemann, Joachim; Thiele, Katja
Zeitschriftenaufsatz
Journal Article
2016 Sustainable enzymatic synthesis of glycolipids in a deep eutectic solvent system
Siebenhaller, S.; Muhle-Goll, C.; Luy, B.; Kirschhöfer, F.; Brenner-Weiss, G.; Hiller, Ekkehard; Günther, Michael; Rupp, S.; Zibek, S.; Syldatk, C.
Zeitschriftenaufsatz
Journal Article
2016 Herstellung langkettiger a,o-Dicarbonsäuren. Mikrobielle Verwertung von nachwachsenden Rohstoffen der zweiten Generation
Riepe, Bianca; Vater, Björn; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2016 pH-driven self-assembly of acidic microbial glycolipids
Baccile, Niki; Selmane, Mohamed; Griel, Patrick le; Prévost, Sylvain; Perez, Javier; Stevens, Christian V.; Delbeke, Elisabeth; Zibek, Susanne; Guenther, Michael; Soetaert, Wim; Bogaert, Inge N.A. van; Roelants, Sophie
Zeitschriftenaufsatz
Journal Article
2016 ChitoTex - development and production of new insect chitosan and chitosan-based functional coatings for textiles
Hahn, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2016 Optimization and scale-up of inulin extraction from Taraxacum kok-saghyz roots
Hahn, Thomas; Klemm, Andrea; Zieße, Patrick; Harms, Karsten; Wach, Wolfgang; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Expression of a codon-optimized Carica papaya papain sequence in the methylotrophic yeast pichia pastoris
Werner, Nicole; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Transcriptomic profiling of Pseudozyma aphidis during mannosylerythritol lipid synthesis
Günther, Michael; Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Hirth, Thomas; Sohn, Kai; Zibek, Susanne; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2015 Enzymatic hydrolysis of solid substrates: Critical notes and experimental guidelines for improvements
Hahn, Thomas; Haitz, Fabian; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Lipase-catalyzed epoxidation of fatty compounds and alkenes
Haitz, Fabian; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne
Aufsatz in Buch
Book Article
2015 Draft genome sequence of Amantichitinum ursilacus IGB-41, a new chitin-degrading bacterium
Kirstahler, Philipp; Günther, Michael; Grumaz, Christian; Lindemann, Elena; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2015 Development of new biocatalysts and process optimization for the production of long-chain a,o-dicarboxylic acids
Werner, Nicole; Riepe, Bianca; Vater, Björn; Geiger, Georg; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Integrierte Bioproduktion - Pflanzliche Öle für die chemische Industrie
Torkler, Sandra; Haitz, Fabian; Zibek, Susanne; Patzsch, Katja; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2015 Enzymatische Verzuckerung von Lignozellulose
Vater, Björn; Hirth, Thomas; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2015 The transcriptomic profile of Pseudozyma aphidis during production of mannosylerythritol lipids
Günther, Michael; Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Hirth, Thomas; Sohn, K.; Zibek, S.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2015 Vom Schüttelkolben in die Pilotanlage: Enzymherstellung in Hefen
Werner, Nicole; Vater, B.; Elter, T.; Patzsch, K.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2015 Identification of new CALB-type lipases within the genus Pseudozyma
Sabatini, Selina; Schultz, Elisabeth; Helber, Nicole; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2014 Neue Enzyme für eine Methanol-basierte grüne Chemie
Zibek, Susanne; Blaschke, Lisa; Hirth, Thomas; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2014 Entwicklung neuer Biokatalysatoren für die Herstellung von langkettigen Dicarbonsäuren
Helber, Nicole; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2014 High solids enzymatic hydrolysis of pretreated lignocellulosic materials with a powerful stirrer concept
Ludwig, D.; Buchmann, M.; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2014 Herstellung biozertifizierter Kosmetika aus nachwachsenden Rohstoffen
Vásquez-Caicedo, Ana Lucia; Zibek, Susanne; Rupp, Steffen; Egner, Siegfried
Zeitschriftenaufsatz
Journal Article
2014 Neue Verfahren für die Ligninmodifikation am Beispiel der Natur
Zibek, Susanne; Rais, Dominik; Rupp, Steffen; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2014 Enzymatische Verzuckerung von Lignozellulose
Vater, Björn; Hirth, Thomas; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2014 Herstellung von Enzymen - Maßstabsübertragung vom Laborprozess zur Pilotanlage
Helber, Nicole; Vater, Björn; Haitz, Fabian; Torkler, Sandra; Patzsch, Katja; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2014 Integrierte Bioproduktion - Integrierte chemisch-biotechnologische Herstellung von Synthesebausteinen auf der Basis pflanzlicher Öle
Zibek, Susanne; Rupp, Steffen; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2014 Synthese von Mannosylerythritollipide von Pseudozyma-Spezies mit nachwachsenden Rohstoffen
Zibek, Susanne; Hirth, Thomas; Rupp, Steffen; Carrillo Riveros, Paula Alejandra
Zeitschriftenaufsatz
Journal Article
2014 Demonstration der fermentativen Herstellung von Isobuten im Pilotmaßstab
Elter, Tino; Buhl, T.
Zeitschriftenaufsatz
Journal Article
2014 Optimierung und Scale-up der enzymatischen Hydrolyse inkl. Ligninabbau
Tippkötter, Nils; Duwe, Anna; Rais, Dominik; Zibek, Susanne; Zorn, H.
Zeitschriftenaufsatz
Journal Article
2014 Identifizierung neuer bakterieller Lignin-modifizierender Enzyme
Zibek, Susanne; Rais, Dominik; Rupp, Steffen; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2014 Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids
Lorenz, Stefan; Günther, Michael; Grumaz, Christian; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2013 Amantichitinum ursilacus gen. nov., sp nov., a chitin-degrading bacterium isolated from soil
Moß, K.; Hartmann, S.C.; Müller, I.; Fritz, C.; Krügener, Sven; Zibek, S.; Hirth, Thomas; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2013 Lignin als nachwachsende Rohstoffquelle
Staiger, Nadine; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2013 Lokale chemische Stimulation von Zelllinien durch Dispensieren von Tropfen mit dem StimuDrop
Zibek, S.
Dissertation
Doctoral Thesis
2013 Characterization of novel mutants with an altered gibberellin spectrum in comparison to different wild-type strains of Fusarium fujikuroi
Albermann, S.; Elter, T.; Teubner, A.; Krischke, W.; Hirth, Thomas; Tudzynski, B.
Zeitschriftenaufsatz
Journal Article
2013 Development and optimization of single and combined detoxification processes to improve the fermentability of lignocellulose hydrolyzates
Ludwig, D.; Amann, M.; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2013 Herstellung Pflanzenöl-basierter Epoxide
Haitz, Fabian; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2013 Produktion von Biotensiden mit Pseudozyma-Stämmen
Günther, Michael; Hirth, Thomas; Zibek, S.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2012 Comparison of chemo-enzymatic epoxidation of oleic acid with different immobilized lipases
Haitz, Fabian; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Konferenzbeitrag
Conference Paper
2012 Process development for high-solid enzymatic conversion of lignocellulose within a biorefinery
Ludwig, Daniel; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Konferenzbeitrag
Conference Paper
2012 Untersuchungen zur Synthese von optimierten Mannosylerythritollipiden
Zibek, S.; Günther, Michael; Hirth, Thomas; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2012 Selektive Konversion lignocellulosehaltiger Materialien als Plattformtechnologie für biobasierte Chemikalien
Zibek, S.; Ludwig, D.; Hirth, Thomas; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2012 Untersuchung der Stickstoffregulation der Gibberellin-Synthese von Fusarium fujikuroi
Elter, T.; Albermann, S.; Krischke, W.; Hirth, Thomas; Tudzynski, B.
Zeitschriftenaufsatz
Journal Article
2012 Milchsäurebakterien für die Herstellung von Milchsäure aus Weizenstroh
Zibek, S.; Gronen, A.; Hirth, Thomas; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2012 Stoffliche Nutzung von Lignin. Ein Beitrag zur ganzheitlichen stofflichen Nutzung von Biomasse. Tl. 2: Chemische und biochemische Spaltung von Lignin in Aromaten
Hirth, Thomas; Unkelbach, G.; Zibek, S.; Staiger, Nadine; Leschinsky, Moritz
Zeitschriftenaufsatz
Journal Article
2011 Chitin-converting enzymes
Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S.
Aufsatz in Buch
Book Article
2011 Chemo-enzymatic epoxidation of fatty acids and triacylglycerides from various plant oils
Haitz, Fabian; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Konferenzbeitrag
Conference Paper
2011 Biobasierte Monomere und Polymere
Hirth, Thomas; Fehrenbacher, Ulrich; Kowollik, Kristian; Krischke, Wolfgang; Krügener, Sven; Rupp, Steffen; Schweppe, Rainer; Unkelbach, Gerd; Zibek, Susanne
Aufsatz in Buch
Book Article
Diese Liste ist ein Auszug aus der Publikationsplattform Fraunhofer-Publica

This list has been generated from the publication platform Fraunhofer-Publica
Jahr
Year
Titel/Autor:in
Title/Author
Publikationstyp
Publication Type
2011 Co-cultured production of lignin-modifying enzymes with white-rot fungi and its potential application
Krügener, Sven; Qi-he, Chen; Hirth, Thomas; Zibek, Susanne; Rupp, Steffen
Konferenzbeitrag
Conference Paper
2011 Co-cultured production of lignin-modifying enzymes with white-rot fungi
Qi-he, C.; Krügener, Sven; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2011 Biotechnological synthesis of long-chain dicarboxylic acids as building blocks for polymers
Huf, Sabine; Krügener, Sven; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2011 From lignocellulose to platform chemicals
Ludwig, Daniel; Gronen, Angela; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Konferenzbeitrag
Conference Paper
2010 Screening for microorganisms for the synthesis of acetic acid and lactic acid out of wheat straw hydrolysate at low pH
Gronen, A.; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Synthese und Optimierung von Cellobioselipiden und Mannosylerythritollipiden
Rupp, S.; Zibek, S.; Günther, M.; Hirth, Thomas
Konferenzbeitrag
Conference Paper
2010 Wheat straw - making a natural carbon source accessible for industry
Ludwig, Daniel; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Weizenstroh - Eine potenzielle Rohstoffquelle für die chemische Industrie
Ludwig, D.; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2010 Production of alpha-, omega-dicarboxylic acids via biotransformation of fatty acids by the use of Candida tropicalis
Huf, S.; Wagner, Wenke; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Biotechnological process development for the production of C5 and C6 sugars as bio-based building blocks from lignocellulose
Ludwig, Daniel; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Laccase-katalysierte Detoxifizierung von löslichen Ligninabbauprodukten in vorbehandelten Lignocellulose-Hydrolysaten
Zibek, S.; Rupp, S.; Hirth, Thomas; Amann, M.; Ludwig, Daniel
Konferenzbeitrag
Conference Paper
2010 Production and optimization of cellobiose lipids and mannosylerythritol lipids
Günther, M.; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Stoffliche Nutzung von Lignocellulose - Detoxifikation von Aufschlusslösungen mit immobilisierter Laccase
Ludwig, D.; Amann, M.; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2010 Mikroorganismen zur stofflichen Nutzung von Stroh-Hydrolysat
Gronen, A.; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2010 Expression of codon optimized Bacillus cereus Phospholipase C in Kluyveromyces lactis
Krügener, Sven; Hirth, Thomas; Zibek, S.; Rupp, S.
Konferenzbeitrag
Conference Paper
2010 Selective synthesis and tailoring of glycolipid biosufactants
Günther, M.; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Mikrobielle Synthese von Biotensiden
Günther, Michael; Zibek, S.; Hirth, Thomas; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2010 Identification of yeast strains for the synthesis of a,w-dicarboxylic acids
Huf, S.; Wagner, Wenke; Hirth, Thomas; Zibek, S.; Rupp, S.
Konferenzbeitrag
Conference Paper
2010 New chitinolytic organisms for the degradation of chitin to N-acetylglucosamine
Moß, K.; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Wheat straw - making a natural carbon source accessible for industry
Ludwig, Daniel; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Production of a,w-dicarboxylic acids via biotransformation of fatty acids by the use of Candida tropicalis
Huf, S.; Wagner, Wenke; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2010 Identification of qualified microorganisms for the usage of wheat straw hydrolysate for the synthesis of acetic acid and lactic acid
Gronen, A.; Hirth, Thomas; Rupp, S.; Zibek, S.
Konferenzbeitrag
Conference Paper
2009 Prozessentwicklung zur Herstellung von NAG mit neuen Chitinasen
Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S.
Konferenzbeitrag
Conference Paper
2009 New chitinases for the industrial biotechnology
Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S.
Konferenzbeitrag
Conference Paper
2009 Fermentative Herstellung der α,ω-Dicarbonsäure 1,18-Oktadecendisäure als Grundbaustein für biobasierte Kunststoffe
Zibek, Susanne; Huf, Sabine; Wagner, Wenke; Hirth, Thomas; Rupp, S.
Zeitschriftenaufsatz
Journal Article
Diese Liste ist ein Auszug aus der Publikationsplattform Fraunhofer-Publica

This list has been generated from the publication platform Fraunhofer-Publica

Group photo »Bioprocess scale-up«
© Fraunhofer CBP
Group photo »Bioprocess scale-up«