Bioprocess scale-up

We have a broad bioprocess engineering know-how for process intensification and scale-up, whereby the processes developed on a laboratory scale are evaluated in advance with regard to their transferability to the industrial relevant scale and optimized iteratively during transfer and scale-up. These include the adaptation of process control strategies (batch, fed-batch, continuous) and integrated product purification to reduce process steps or the reuse of biocatalysts (e.g. by immobilization on carrier materials). In addition to the scale-up of processes to demonstration scale, we also provide sample quantities for application tests.

Fields of activity and technologies


Fermentative production of carboxylic acids

We are developing new economical processes for the sustainable production of malic, xylon and itaconic acid from lignocellulosic sugars. We have successfully demonstrated the production of malic acid from xylose on a 1 m³ scale.

Enzyme production and biocatalysis

Together with our customers, we develop, optimize and/or scale up the production of enzymes up to pilot scale. The enzyme can be purified for biocatalysis or whole-cell catalysis can be carried out.


Reference: Process demonstration isobutene

A novel process for the production of isobutene developed by the company Global Bioenergies is based on the fermentative production of gaseous isobutene from sugars using genetically modified microorganisms. To scale up this process, we have built up and operated a demonstration plant with a nominal capacity of 100 tonnes per year and a fermentation volume of 5000 liters.

Reference projects

Enzyme production