Therapeutic viruses

The Infection Biology and Array Technologies working group also develops virus-based therapies. Virus-like particles (VLP) are bio-based capsules that mimic viruses. The VLP's surface can be equipped with antigens, thus enabling the application of VLPs as a vaccine. Alternatively, VLPs provide a vehicle for targeted "drug delivery".

The production of virus variants by genome engineering methods such as bacterial artifical chromosome (BAC) is another expertise of the working group.

 

Reference projects

TheraVision – Platform technology for the development, production and testing of oncolytic viruses

 

In order to optimize oncolytic viruses for therapeutic use, a consortium of the Fraunhofer Institutes ITEM, ISC, IZI, and ITWM, coordinated by Fraunhofer IGB, is developing a broadly applicable platform technology for combined oncolytic virus immunotherapy in the TheraVision project. An oncolytic virus for the treatment of non-small cell lung cancer is being developed as a proof of concept.

 

Duration: April 2017 – December 2020