Bioprocess Engineering

The use of renewable raw materials and biogenic residues in sustainable production processes offers alternative solutions for chemistry based on fossil raw materials. Particular importance is attached to white/industrial biotechnology, which produces platform and fine chemicals as well as fuels using biotechnological or combined processes. Biogenic raw materials such as lignocellulose or vegetable oils are preferred in such biorefinery concepts in order to obtain environmentally compatible products.

Research in the field of industrial, white biotechnology at Fraunhofer IGB is performed in an interdisciplinary manner. The activities of the Industrial Biotechnology Group headed by Dr. Susanne Zibek focus on establishing, optimizing and upscaling biotransformation processes in which raw materials are transformed into usable products either with the aid of microorganisms or enzymes. We combine the development of transformation processes on a laboratory scale and the optimization of the biocatalysts themselves with the transfer of the processes to larger scales. In addition, we can increase the scale up to the pilot scale either at our customers' and project partners' facilities or at the Fraunhofer Center for Chemical-Biotechnological Processes CBP.

With our interdisciplinary orientation in biology, chemistry and process engineering, we cover the entire process chain and create the prerequisites for the scalability of our processes already at the laboratory scale. Cooperation with a wide variety of project partners from industry enables us to develop ecologically and economically sensible, sustainable future technologies.

Research areas

 

Fermentative production of chemicals and biosurfactants

For the production of basic chemicals and biosurfactants, we establish fermentation processes and carry out model tests for scale-up in scale down fermenters. To increase space-time yields, we optimize biomass and product formation, e.g. by varying process operation and developing customized culture media.

 

Establishment and scale-up of technical enzyme processes

Fraunhofer IGB develops enzyme conversion processes from laboratory to pilot plant scale and designs the scale-up of these processes. Variable stirring reactors and continuous fixed-bed reactors are used. The highly scaled processes can be implemented either at Fraunhofer CBP or at project partners and customers.

 

Upstream processing of renewable raw materials and biogenic residues

We use shrimp and insect chitin, lignocellulose, dandelion roots and agricultural residues to produce valuable intermediates such as chitosan, sugar monomers, rubber and phosphate. Thus, renewable raw materials and waste materials are utilized with sustainable added value.

 

Enzyme screening and production of biocatalysts

We are concerned with the screening for new, industrially usable enzymes and the optimized recombinant production of these enzymes. Alternatively, we use microorganisms as biocatalysts, which we isolate from various sources or optimize for the desired process with the help of metabolic analyses.

Strain development

  • Creation of vectors (fusion proteins for purification, secretion, immune assays)
  • Metabolic engineering: knock out or overexpression of genes
  • Overexpression of enzymes in pro- and eucaryotic systems


Bioprocess technology

  • Development of scalable fractionation and/or conversion processes of waste streams to valuable raw materials (chitin, insect fats, etc.) with combinations of mechanical, enzymatic and high pressure processes.
  • Development of production processes for bio based chemicals and materials (e.g. biosurfactants)
  • Development and optimization of enzyme conversion procedures in stirred tank or fixed bed reactors
  • Development and optimization of scalable fermentation processes
  • Contract fermentation for the production of biomass, enzymes, or metabolites up to 30-L scale under S1 and S2 conditions and up to 10 m3 scale (S1) at Fraunhofer CBP
  • Development of purification methods (e.g. biomass separation, filtration, normal phase chromatography, precipitation, solvent extraction)
  • Process intensification for the increase in the space-time yield

Molecular biology

  • Thermal cycler to amplify segments of DNA via the polymerase chain reaction
  • Agarose gel electrophoresis and polyacrylamide gel electrophoresis (PAGE)


Incubators and anaerobic workbench

  • Several temperature-controlled incubators and incubation shakers
  • Anaerobic workbench

 

Chemical and enzymatic reaction systems

  • Temperature-controlled shakers for 24 parallel approaches (2 to 20 ml scale)
  • Temperature-controlled stirring system for 6 parallel approaches (30 to 200ml scale)
  • Glass reactors with several different stirrer geometries and baffles (1 l and 10 l scale)

 

Fermenters and bioreactors

  • Micro-bioreactor for up to 48 parallel fermentations on a (1.5 ml scale)
  • Multi-fermenter-system for up to 8-times the parallel approaches (1.2 l scale, biological security level S2)
  • Multi-fermenter-systems for 3 x 4-times the parallel approaches (1.5 l scale, biological security level 1)
  • Small-scale fermenter (each 2 x 3.6 l and 7 l scale, biological security level S2)
  • Fermenter of the technical center (42 l scale, biological security level S2)
  • Accompanying process control systems including exhaust gas analysis for the regulation of Fed-Batch processes with different supplementary feeding processes


Digestion equipment

  • High-pressure reactor – (1 l scale), e.g., for pulping bio mass
  • Inline-disperser (up to 350 l/h) with several applications for the homogenization and production of emulsions and dispersions
  • Ultrasonic laboratory homogenizer for cell disruption, homogenization and degassing with different attachments (sonotrode, volume up to 15ml)
Anaerobank - Bioprozessentwicklung
© Fraunhofer IGB
Anaerobic workbench
Bioreaktor
© Fraunhofer IGB
Laboratory pilot fermenter LP351 (42 L)
Bioreactor system
© Fraunhofer IGB
Bioreactor system

Downstream Processing

  • Disc separator to separate fermentation broths
  • Crossflow filtration systems for micro- and ultrafiltration with ceramic or polymeric hollow fiber modules (50-2000 cm² membrane surface)
  • Automated flash-chromatography for the purification of metabolites
  • Continuous rotating evaporator with automated sample supplying and residue drainage


Analysis 

  • Automatic DC applicaton equipment
  • HPLC- and GPC systems with RI-, UV-, und ELSD-detectors
  • Photometric analyzers and multiwell reader
  • Multi-enzyme and ion-selective detector (YSI 2950D)
  • Microscope (Zeiss, phase and fluorescence contrast, incl. AxioCam camera)

 

HPLC - Bioprozessentwicklung
© Fraunhofer IGB
HPLC
HPLC - Bioprozessentwicklung
© Fraunhofer IGB
HPLC
HPLC - Bioprozessentwicklung
© Fraunhofer IGB
HPLC

Information materials

 

Brochure “Industrial biotechnology - Nature´s own chemical plant”

 

Product sheet “Production of optimized biosurfactants”

Publications

Jahr
Year
Titel/Autor:in
Title/Author
Publikationstyp
Publication Type
2024 Process Cascade for the Production of Green Polymers from CO2 and Electric Energy
Fabarius, Jonathan Thomas; Pietzka, Carsten; Pangotra, Dhananjai; Wriedt, Benjamin; Vieira Dessoy Maciel, Luciana; Sagstetter, Carina; Speck, Melanie; Ziogas, Athanassios; Baumgarten, Nils; Kost, Hans-Joachim; Löb, Patrick; Patzsch, Katja; Bernau, Catherine Rose; Böringer, Sarah; Pico, Davide; Lieske, Antje; Vater, Marcus; Wendler, Ulrich; Roth, Arne
Zeitschriftenaufsatz
Journal Article
2024 Current trends in medium-chain-length polyhydroxyalkanoates: Microbial production, purification, and characterization
Hahn, Thomas; Ortega Alzate, Melissa; Leonhardt, Steven; Tamang, Pravesh; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2024 Comprehensive characterization and evaluation of the process chain and products from Euphausia superba exocuticles to chitosan
Hahn, Thomas; Egger, Jeannine; Krake, Simon; Dyballa, Michael; Stegbauer, Linus; Seggern, Nils von; Bruheim, Inge; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2024 Life cycle assessment for early-stage process optimization of microbial biosurfactant production using kinetic models - a case study on mannosylerythritol lipids (MEL)
Bippus, Lars; Briem, Ann-Kathrin; Beck, Alexander; Zibek, Susanne; Albrecht, Stefan
Zeitschriftenaufsatz
Journal Article
2024 Transmembrane Chemical Absorption Process for Recovering Ammonia as an Organic Fertilizer Using Citric Acid as the Trapping Solution
Reyes Alva, Ricardo; Mohr, Marius; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2024 Life cycle assessment as a driver for process optimisation of cellobiose lipids fermentation and purification
Oraby, Amira; Briem, Ann-Kathrin; Bippus, Lars Ulrich; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2024 Past, present and future of glycolipids from Ustilaginaceae - A review on cellobiose lipids and mannosylerythritol lipids
Münßinger, Sini; Beck, Alexander; Oraby, Amira; Zibek, Susanne
Review
2023 Fermentation and recovery of cellobiose lipids using foam fractionation
Oraby, Amira; Hug, Daniel; Weickardt, Isabell; Maerz, Lea; Nebel, Sabrina; Kurmann, Jasper; Rupp, Steffen; Tovar, Günter E.M.; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2023 Usage of chitosan from Hermetia illucens as a preservative for fresh Prunus species fruits: a preliminary analysis
Triunfo, Micaela; Tafi, Elena; Guarnieri, Anna; Ianniciello, Dolores; Scieuzo, Carmen; Salvia, Rosanna; Hahn, Thomas; Zibek, Susanne; Falabella, Patrizia
Zeitschriftenaufsatz
Journal Article
2023 Preliminary investigation on the effect of insect-based chitosan on preservation of coated fresh cherry tomatoes
Tafi, Elena; Triunfo, Micaela; Guarnieri, Anna; Ianniciello, Dolores; Salvia, Rosanna; Scieuzo, Carmen; Ranieri, Annamaria; Castagna, Antonella; Lepuri, Samuel; Hahn, Thomas; Zibek, Susanne; Bonis, Angela de; Falabella, Patrizia
Zeitschriftenaufsatz
Journal Article
2022 Techno-Economic Analysis as a Driver for Optimisation of Cellobiose Lipid Fermentation and Purification
Oraby, Amira; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2022 Optimization and Kinetic Modeling of a Fed-Batch Fermentation for Mannosylerythritol Lipids (MEL) Production with Moesziomyces aphidis
Beck, Alexander; Vogt, Franziska; Hägele, Lorena; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2022 Environmental Impacts of Biosurfactants from a Life Cycle Perspective
Briem, Ann-Kathrin; Bippus, Lars; Oraby, Amira; Noll, Philipp; Zibek, Susanne; Albrecht, Stefan
Aufsatz in Buch
Book Article
2022 Purification of Chitin from Pupal Exuviae of the Black Soldier Fly
Hahn, T.; Tafi, E.; Seggern, N. von; Falabella, P.; Salvia, R.; Thomä, J.; Febel, E.; Fijalkowska, M.; Schmitt, E.; Stegbauer, L.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2022 Characterization of chitin and chitosan derived from Hermetia illucens, a further step in a circular economy process
Triunfo, M.; Tafi, E.; Guarnieri, A.; Salvia, R.; Scieuzo, C.; Hahn, Thomas; Zibek, Susanne; Gagliardini, A.; Panariello, L.; Coltelli, M.B.; Bonis , A. De; Falabella, P.
Zeitschriftenaufsatz
Journal Article
2022 Antimicrobial properties of chitosan from different developmental stages of the bioconverter insect Hermetia illucens
Guarnieri, A.; Triunfo, M.; Scieuzo, C.; Ianniciello, D.; Tafi, E.; Hahn, Thomas; Zibek, Susanne; Salvia, R.; Bonis, A. De; Falabella, P.
Zeitschriftenaufsatz
Journal Article
2022 Foam fractionation methods in aerobic fermentation processes
Oraby, Amira; Weickardt, Isabell; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2022 Overview on Glycosylated Lipids Produced by Bacteria and Fungi: Rhamno-, Sophoro-, Mannosylerythritol and Cellobiose Lipids
Zibek, Susanne; Soberón-Chávez, Gloria
Aufsatz in Buch
Book Article
2021 Platform and fine chemicals from woody biomass: Demonstration and assessment of a novel biorefinery
Nitzsche, R.; Gröngröft, A.; Köchermann, J.; Meisel, K.; Etzold, H.; Verges, Marlen; Bachmann, J.; Leschinsky, Moritz; Saake, B.; Torkler, Sandra; Rößiger, B.; Patzsch, Katja; Pufky-Heinrich, D.; Unkelbach, Gerd
Zeitschriftenaufsatz
Journal Article
2021 Genomic and Proteomic Study of Andreprevotia ripae Isolated from an Anthill Reveals an Extensive Repertoire of Chitinolytic Enzymes
Lorentzen, S.B.; Arntzen, M.; Hahn, T.; Tuveng, T.R.; Sorlie, M.; Zibek, S.; Vaaje-Kolstad, G.; Eijsink, V.G.H.
Zeitschriftenaufsatz
Journal Article
2021 Novel mannosylerythritol lipid biosurfactant structures from castor oil revealed by advanced structure analysis
Beck, A.; Haitz, Fabian; Thier, I.; Siems, K.; Jakupovic, S.; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2021 Insect Chitin-Based Nanomaterials for Innovative Cosmetics and Cosmeceuticals
Triunfo, M.; Tafi, E.; Guarnieri, A.; Scieuzo, C.; Hahn, T.; Zibek, S.; Salvia, R.; Falabella, P.
Review
2020 Draft Genome Sequence of Andreprevotia sp. Strain IGB-42, a Chitinolytic Bacterium Isolated from a Soil Sample of an Anthill in Stuttgart, Germany
Vainshtein, Y.; Werner, Nicole; Kirstahler, Philipp; Glanz, K.; Grumaz, Christian; Hahn, T.; Zibek, S.; Sohn, K.
Zeitschriftenaufsatz
Journal Article
2020 Chitosan application in textile processing and fabric coating
Hahn, Thomas; Bossog, Leonie; Hager, Tom; Wunderlich, Werner; Breier, Rudi; Stegmaier, TThomas; Zibek, Susanne
Aufsatz in Buch
Book Article
2020 Mannosylerythritollipide - mikrobielle Biotenside aus dem Bioreaktor
Beck, A.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Antibacterial properties of glycosylated surfaces: Variation of the glucosidal moiety and fatty acid conformation of grafted microbial glycolipids
Valotteau, C.; Roelants, S.L.K.V.; Dasaiyan, P.; Zibek, S.; Günther, Michael; Soetaert, W.; Everaert, B.; Pradier, C.-M.; Babonneau, F.; Baccile, N.; Humblot, V.
Zeitschriftenaufsatz
Journal Article
2020 Factors Affecting the Synthesis of Cellobiose Lipids by Sporisorium scitamineum
Oraby, Amira; Werner, Nicole; Sungur, Z.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Determining different impact factors on the xylonic acid production using Gluconobacter oxydans DSM 2343
Hahn, T.; Torkler, S.; Bolt, R. van der; Gammel, N.; Hesse, M.; Möller, A.; Preylowski, B.; Hubracht, V.; Patzsch, K.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Growth Behavior of Selected Ustilaginaceae Fungi Used for Mannosylerythritol Lipid (MEL) Biosurfactant Production - Evaluation of a Defined Culture Medium
Beck, A.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Comparison of Different Lactobacilli Regarding Substrate Utilization and their Tolerance Towards Lignocellulose Degradation Products
Gubelt, A.; Blaschke, Lisa; Hahn, Thomas; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2020 Chitosan production with larval exoskeletons derived from the insect protein production
Hahn, T.; Roth, A.; Ji, R.; Schmitt, E.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 A systematic analysis of economic evaluation studies of second-generation biorefineries providing chemicals by applying biotechnological processes
Jorissen, T.; Oraby, Amira; Recke, G.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2020 Current state of chitin purification and chitosan production from insects
Hahn, T.; Tafi, E.; Paul, A.; Salvia, R.; Falabella, P.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2019 Biotechnological and biochemical utilization of lignin
Rais, Dominik; Zibek, Susanne
Aufsatz in Buch
Book Article
2019 Selection and optimization of a suitable pretreatment method for miscanthus and poplar raw material
Seibert-Ludwig, Daniel; Hahn, Thomas; Hirth, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2019 Influence of microorganism and plant oils on the structure of mannosylerythritol lipid (MEL) biosurfactants revealed by a novel thin layer chromatography mass spectrometry method
Beck, Alexander; Haitz, Fabian; Grunwald, Saskia; Preuss, Laura; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2019 Mannosylerythritol Lipids: Biosynthesis, Genetics, and Production Strategies
Beck, Alexander; Werner, Nicole; Zibek, Susanne
Aufsatz in Buch
Book Article
2019 Integrated lignocellulosic value chains in a growing bioeconomy: Status quo and perspectives
Dahmen, Nicolaus; Lewandowski, Iris; Zibek, Susanne; Weidtmann, Annette
Zeitschriftenaufsatz
Journal Article
2019 Stirrer speed adaption is beneficial for liquefaction of cellulose
Hahn, Thomas; Nothacker, Matthias; Kövilein, Aline; Beck, Alexander; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2018 Entwicklung von Verfahren zur enzymatischen Epoxidierung von Pflanzenölen und Fettsäurederivaten
Haitz, F.
Dissertation
Doctoral Thesis
2018 Sewage Polluted Water Treatment via Chitosan. A Review
Hahn, Thomas; Zibek, Susanne
Aufsatz in Buch
Book Article
2018 Chemo-Enzymatic Epoxidation of Lallemantia IbericaSeed Oil
Haitz, Fabian; Radloff, S.; Rupp, S.; Fröhling, M.; Hirth, Thomas; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2018 New methods for high-accuracy insect chitin measurement
Hahn, T.; Roth, A.; Febel, E.; Fijalkowska, M.; Schmitt, E.; Arsiwalla, T.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2018 Unkraut kann auch anders. Handschuhe aus Russischem Löwenzahn
Hahn, Thomas; Abele, A.; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Verfahren zur Herstellung von Epoxiden mit Hilfe von Enzymen mit Perhydrolaseaktivität
Zibek, Susanne
Patent
2017 Mannosylerythritol- und Cellobioselipide
Hahn, T.; Haitz, Fabian; Schäper, N.; Carrillo Riveros, P.; Günther, Michael; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2017 Biotechnological production of bio-based long-chain dicarboxylic acids with oleogenious yeasts
Werner, Nicole; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Neue Biokatalysatoren zur Herstellung langkettiger Dicarbonsäuren
Werner, Nicole; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Development of a simplified purification method for a novel formaldehyde dismutase variant from Pseudomonas putida J3
Blaschke, Lisa; Werkmeister, Christina; Wagner, Wenke; Wild, Marion; Gihring, Adrian; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Fungal Glycolipids as Biosurfactants
Günther, Michael; Zibek, S.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2017 Biotechnological Routes Towards Bio-based Surfactants
Schörken, U.; Barbe, S.; Hahn, T.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2017 Candida guilliermondii as a potential biocatalyst for the production of long-chain a,o-dicarboxylic acids
Werner, Nicole; Dreyer, Miriam; Wagner, Wenke; Papon, Nicolas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2017 Beechwood carbohydrates for enzymatic synthesis of sustainable glycolipids
Siebenhaller, S.; Hajek, T.; Muhle-Goll, C.; Himmelsbach, M.; Luy, B.; Kirschhöfer, F.; Brenner-Weiß, G.; Hahn, T.; Zibek, S.; Syldatk, C.
Zeitschriftenaufsatz
Journal Article
2017 Draft genome sequence of Pseudonocardia autotrophica strain DSM 43083, an efficient producer of peroxidases for lignin modification
Grumaz, Christian; Rais, Dominik; Kirstahler, Philipp; Vainshtein, Yevhen; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2017 Sustainable carbon sources for microbial organic acid production with filamentous fungi
Dörsam, S.; Fesseler, J.; Gorte, O.; Hahn, T.; Zibek, S.; Syldatk, C.; Ochsenreither, K.
Zeitschriftenaufsatz
Journal Article
2016 Fermentative production and characterization of several tailor-made mannosylerythritol lipids
Zibek, Susanne; Günther, Michael; Carillo-Riveros, Paula; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2016 Enzymatische Synthese von Biotensiden aus der Cellulosefraktion des Organosolvprozesses
Siebenhaller, Sascha; Hajek, T.; Zibek, Susanne; Syldatk, Christoph
Zeitschriftenaufsatz
Journal Article
2016 Chitin-converting enzymes
Moß, K.; Zibek, S.; Hirth, Thomas; Rupp, S.
Aufsatz in Buch
Book Article
2016 Optimization and scale-up of inulin extraction from Taraxacum koksaghyz
Hahn, Thomas; Harms, Karsten; Wach, Wolfgang; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2016 Scale-up of the chemo-enzymatic epoxidation
Haitz, Fabian; Rupp , Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2016 Seasonal pattern of biomass and rubber and inulin of wild Russian dandelion (Taraxacum koksaghyz L. Rodin) under experimental field conditions
Kreuzberger, Marie; Hahn, Thomas; Zibek, Susanne; Schiemann, Joachim; Thiele, Katja
Zeitschriftenaufsatz
Journal Article
2016 Sustainable enzymatic synthesis of glycolipids in a deep eutectic solvent system
Siebenhaller, S.; Muhle-Goll, C.; Luy, B.; Kirschhöfer, F.; Brenner-Weiss, G.; Hiller, Ekkehard; Günther, Michael; Rupp, S.; Zibek, S.; Syldatk, C.
Zeitschriftenaufsatz
Journal Article
2016 pH-driven self-assembly of acidic microbial glycolipids
Baccile, Niki; Selmane, Mohamed; Griel, Patrick le; Prévost, Sylvain; Perez, Javier; Stevens, Christian V.; Delbeke, Elisabeth; Zibek, Susanne; Guenther, Michael; Soetaert, Wim; Bogaert, Inge N.A. van; Roelants, Sophie
Zeitschriftenaufsatz
Journal Article
2016 Optimization and scale-up of inulin extraction from Taraxacum kok-saghyz roots
Hahn, Thomas; Klemm, Andrea; Zieße, Patrick; Harms, Karsten; Wach, Wolfgang; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2016 Herstellung langkettiger a,o-Dicarbonsäuren. Mikrobielle Verwertung von nachwachsenden Rohstoffen der zweiten Generation
Riepe, Bianca; Vater, Björn; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2016 ChitoTex - development and production of new insect chitosan and chitosan-based functional coatings for textiles
Hahn, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Expression of a codon-optimized Carica papaya papain sequence in the methylotrophic yeast pichia pastoris
Werner, Nicole; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Lipase-catalyzed epoxidation of fatty compounds and alkenes
Haitz, Fabian; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne
Aufsatz in Buch
Book Article
2015 Transcriptomic profiling of Pseudozyma aphidis during mannosylerythritol lipid synthesis
Günther, Michael; Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Hirth, Thomas; Sohn, Kai; Zibek, Susanne; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2015 Enzymatic hydrolysis of solid substrates: Critical notes and experimental guidelines for improvements
Hahn, Thomas; Haitz, Fabian; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Development of new biocatalysts and process optimization for the production of long-chain a,o-dicarboxylic acids
Werner, Nicole; Riepe, Bianca; Vater, Björn; Geiger, Georg; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Draft genome sequence of Amantichitinum ursilacus IGB-41, a new chitin-degrading bacterium
Kirstahler, Philipp; Günther, Michael; Grumaz, Christian; Lindemann, Elena; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2015 Enzymatische Verzuckerung von Lignozellulose
Vater, Björn; Hirth, Thomas; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2015 The transcriptomic profile of Pseudozyma aphidis during production of mannosylerythritol lipids
Günther, Michael; Grumaz, Christian; Lorenz, Stefan; Stevens, Philip; Lindemann, Elena; Hirth, Thomas; Sohn, K.; Zibek, S.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2015 Identification of new CALB-type lipases within the genus Pseudozyma
Sabatini, Selina; Schultz, Elisabeth; Helber, Nicole; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2015 Vom Schüttelkolben in die Pilotanlage: Enzymherstellung in Hefen
Werner, Nicole; Vater, B.; Elter, T.; Patzsch, K.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2015 Integrierte Bioproduktion - Pflanzliche Öle für die chemische Industrie
Torkler, Sandra; Haitz, Fabian; Zibek, Susanne; Patzsch, Katja; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2014 Optimierung und Scale-up der enzymatischen Hydrolyse inkl. Ligninabbau
Tippkötter, Nils; Duwe, Anna; Rais, Dominik; Zibek, Susanne; Zorn, H.
Zeitschriftenaufsatz
Journal Article
2014 Entwicklung neuer Biokatalysatoren für die Herstellung von langkettigen Dicarbonsäuren
Helber, Nicole; Rupp, Steffen; Hirth, Thomas; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2014 Neue Enzyme für eine Methanol-basierte grüne Chemie
Zibek, Susanne; Blaschke, Lisa; Hirth, Thomas; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2014 High solids enzymatic hydrolysis of pretreated lignocellulosic materials with a powerful stirrer concept
Ludwig, D.; Buchmann, M.; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2014 Neue Verfahren für die Ligninmodifikation am Beispiel der Natur
Zibek, Susanne; Rais, Dominik; Rupp, Steffen; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2014 Enzymatische Verzuckerung von Lignozellulose
Vater, Björn; Hirth, Thomas; Rupp, Steffen
Zeitschriftenaufsatz
Journal Article
2014 Herstellung biozertifizierter Kosmetika aus nachwachsenden Rohstoffen
Vásquez-Caicedo, Ana Lucia; Zibek, Susanne; Rupp, Steffen; Egner, Siegfried
Zeitschriftenaufsatz
Journal Article
2014 Herstellung von Enzymen - Maßstabsübertragung vom Laborprozess zur Pilotanlage
Helber, Nicole; Vater, Björn; Haitz, Fabian; Torkler, Sandra; Patzsch, Katja; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2014 Synthese von Mannosylerythritollipide von Pseudozyma-Spezies mit nachwachsenden Rohstoffen
Zibek, Susanne; Hirth, Thomas; Rupp, Steffen; Carrillo Riveros, Paula Alejandra
Zeitschriftenaufsatz
Journal Article
2014 Integrierte Bioproduktion - Integrierte chemisch-biotechnologische Herstellung von Synthesebausteinen auf der Basis pflanzlicher Öle
Zibek, Susanne; Rupp, Steffen; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2014 Demonstration der fermentativen Herstellung von Isobuten im Pilotmaßstab
Elter, Tino; Buhl, T.
Zeitschriftenaufsatz
Journal Article
2014 Identifizierung neuer bakterieller Lignin-modifizierender Enzyme
Zibek, Susanne; Rais, Dominik; Rupp, Steffen; Hirth, Thomas
Zeitschriftenaufsatz
Journal Article
2014 Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids
Lorenz, Stefan; Günther, Michael; Grumaz, Christian; Rupp, Steffen; Zibek, Susanne; Sohn, Kai
Zeitschriftenaufsatz
Journal Article
2013 Lignin als nachwachsende Rohstoffquelle
Staiger, Nadine; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2013 Amantichitinum ursilacus gen. nov., sp nov., a chitin-degrading bacterium isolated from soil
Moß, K.; Hartmann, S.C.; Müller, I.; Fritz, C.; Krügener, Sven; Zibek, S.; Hirth, Thomas; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2013 Lokale chemische Stimulation von Zelllinien durch Dispensieren von Tropfen mit dem StimuDrop
Zibek, S.
Dissertation
Doctoral Thesis
2013 Characterization of novel mutants with an altered gibberellin spectrum in comparison to different wild-type strains of Fusarium fujikuroi
Albermann, S.; Elter, T.; Teubner, A.; Krischke, W.; Hirth, Thomas; Tudzynski, B.
Zeitschriftenaufsatz
Journal Article
2013 Development and optimization of single and combined detoxification processes to improve the fermentability of lignocellulose hydrolyzates
Ludwig, D.; Amann, M.; Hirth, Thomas; Rupp, S.; Zibek, S.
Zeitschriftenaufsatz
Journal Article
2013 Herstellung Pflanzenöl-basierter Epoxide
Haitz, Fabian; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Zeitschriftenaufsatz
Journal Article
2013 Produktion von Biotensiden mit Pseudozyma-Stämmen
Günther, Michael; Hirth, Thomas; Zibek, S.; Rupp, S.
Zeitschriftenaufsatz
Journal Article
2012 Comparison of chemo-enzymatic epoxidation of oleic acid with different immobilized lipases
Haitz, Fabian; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Konferenzbeitrag
Conference Paper
2012 Process development for high-solid enzymatic conversion of lignocellulose within a biorefinery
Ludwig, Daniel; Hirth, Thomas; Rupp, Steffen; Zibek, Susanne
Konferenzbeitrag
Conference Paper
2012 Milchsäurebakterien für die Herstellung von Milchsäure aus Weizenstroh
Zibek, S.; Gronen, A.; Hirth, Thomas; Rupp, S.
Zeitschriftenaufsatz
Journal Article
Diese Liste ist ein Auszug aus der Publikationsplattform Fraunhofer-Publica

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