As carriers, polymer nanoparticles control the release of effect substances or active ingredients (controlled release). Biodegradable compounds, which are decomposed after their application in the body or in the environment, are becoming increasingly important here. The functional groups of which biodegradable polymers are composed determine the physical and chemical properties such as the rate of release and degradation. The combination of nanoparticles with drug-relevant proteins makes it possible to pursue new drug concepts experimentally. In addition to the possibility of protecting sensitive drugs against biodegradation, nano- and microparticulate carrier systems can also mediate targeted drug release.

Encapsulation of active ingredients

Dosing of active ingredients in a traditional and controlled way.
Dosing of active ingredients in the traditional way (above) and in a controlled way (right) with drug delivery systems.

The release kinetics of the active substances from nano- or microparticles is adapted to the respective problem. The various parameters that influence the kinetics are adjusted according to the customer's requirements. In addition, Fraunhofer IGB also generates tailor-made polymers. In particular, the molecular weight and the ratio of hydrophilic and hydrophobic monomer units influence the release kinetics.

Methods for the encapsulation of active ingredients and effect substances

Different methods are available at Fraunhofer IGB for encapsulating active ingredients and effect substances.

Spray drying

Double emulsion technology

Solvent evaporation

Application areas and references


Spray drying: Perfect encapsulation thanks to three-substance nozzle

Instant coffee and powdered milk are produced by spray drying. Fraunhofer researchers have adapted this technique to the tricky question of incorporating insoluble substances in core-shell particles. The new method helps reduce the concentration of active ingredients in therapeutic medications.


Skin Heal – Particle-based formulation for wound healing

For the treatment of chronic wounds, we have developed particle-based formulations in the Fraunhofer Übermorgen project "SKIN HEAL". The drug-loaded particles can be integrated into commercial wound care dressings or used directly in therapy as pharmaceutical formulations.